Endocrine Abstracts

Introduction: Acromegaly is a rare disease with high morbidity and mortality rates that occurs due to growth hormone (GH) hypersecretion from adenoma in somatotroph cells in the pituitary gland. It is thought that chronically high GH and Insulin-like Growth Factor-I (IGF-1) levels in its pathogenesis increase tissue collagen synthesis due to fibroblast activation. Prolidase enzyme is also the catalyst of the rate-limiting step of collagen synthesis. In our study, we planned to...